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生殖领域顶级会议报道:ESHRS年会专访主席Roy Farquharson教授

2018-07-12 14:06:21

2018年7月1-4日,第34届欧洲人类生殖与胚胎学学会年会(ESHRE)在西班牙巴塞罗那隆重召开,作为生殖领域的世界顶级盛会,俄罗斯ICRM国际生殖医学中心院长克萨科及爱优选大中华区负责人钱军先生受邀参加此次世界顶级会议,就生殖和胚胎学科与国际一流专家共同分享最新的学术成果,传播国际一流的技术,共同讨论学科的热点问题,共同推动辅助生殖技术和胚胎学科的发展。

克萨科院长和钱军先生合影

会议期间,大会主席Roy Farquharson教授接受国内某专业医学媒体的专访,我们也对这次生殖领域的顶级盛会进行了全程跟踪。专访中,Roy Farquharson教授就会议学术主题安排设置和反复流产诊治的未来前景、最新进展及ART后流产的处理经验等问题进行访谈。

Roy Farquharson教授接受国内某专业医学媒体的专访

【专家简介】1975年在阿伯丁获得医学和外科学士学位;1986年在阿伯丁获得医学博士学位;1981年获得皇家妇产科医学院院士(MRCOG)称号;1993年获得皇家妇产科医学院荣誉院士(FRCOG)称号。

1986-2016年,他担任利物浦妇女医院妇产科顾问;1987年,他成立了流产诊所,专注于治疗妇女反复流产,并支持反复流产的调研、病因分析和管理的多学科合作研究。2006-2011年,他担任英国早期妊娠分会协会的主席,ESHRE早期妊娠SIG的协调员。2010-2013年,他任NICE指南小组成员;2014年,担任NICE异位妊娠和流产EUEG小组成员。2011-2015年,他担任ESHRE执行委员会成员,2015-2017年被任命为ESHRE委员会的主席。2010年,他担任剑桥大学出版社出版的《早期妊娠》杂志的联合编辑。2010年至今,他担任《人类生殖医学前沿》的副主编。

1、Good Afternoon,Mr.Farquharson.First let me wish the congress a complete success.The annual meeting of ESHER has a global influence in the field of human reproduction and embryology.As the chairman of ESHER,would you please briefly introduce the overall situation,the themes and the arrangement of the congress.

Roy Farquharson教授,下午好!首先预祝大会成功召开。ESHER 年会在生殖领域可谓是全球非常有影响力的大会,您作为ESHER的大会主席,请您介绍下本次大会情况,以及大会学术主题和内容的安

Pro.Farquharson  2018ESHRE年会大会主席:Thank you!As you know it is the 34th meeting of the European Society of Human Reproduction and Embryology annual meeting in Barcelona,Spain.We are looking forward to attracting probably 11,000 participants at the meeting this year.Our aims are education,training,practice and research.So this year we had a recorded number of abstracts submitted for research projects up to eighteen hundred ninety six were submitted.So of these,the best 225 for lecture presentations and about 800 posters as well,can be read online at the meeting.So overall,we are very pleased with the continuing response.And for the first time this year,we also have a festival attached the conference.But some of the quality of the studies has been very impressive.So I am very much looking forward to groundbreaking studies,new information,new insights into what we can do to improve the patients'experience of assisted Reproduction,ART,and hopefully, creating the family the desire.But we are at the beginning of the congress,full of optimism.And I'm sure that will continue for the next three days.

谢谢!这是第34届欧洲人类生殖和胚胎学学会年会,在西班牙巴塞罗那召开。我们期待着今年或许可以吸引11000名参会者。我们的目标是教育、培训、实践和研究。所以今年我们收到了大量的摘要,多达1896份。所以我们从中选取了225份最好的摘要,邀请其研究者参会演讲,另有约800份展出并可以在线阅读。总的来说,很高兴ESHRE年会持续被关注。今年,首次将年会和我们的节日一起举办。其中,一些研究的质量真是让人印象深刻。所以我非常期待更多的开创性的研究、改善病人的辅助生殖体验方面的新信息、新见解,同时,我们也期待能燃起家庭的希望。现在,这次年会才刚刚开始,充满着积极的氛围,我相信这样积极的氛围将会在未来的三天持续下去。

2、We know you are an expert in recurrent abortion,would you please share your experience in diagnosing and treating spontaneous abortion?

您长期致力于反复流产方面的研究,能否请您分享一下您在反复自然流产诊断与治疗策略方面的经验?

Pro.Farquharson  2018ESHRE年会大会主席:Yes,I'm very happy to share it.It's been a subject of study for our pregnancy group for the ESHER for many years.Recurrent pregnancy loss is very distressing condition for the couple.There are many units dedicated clinic to the recurrent pregnancy loss and the most recent ESHER guidelines this year is on recurrent pregnancy loss,give a very excellent evidence based on the analysis of the management and treatment for recurrent pregnancy loss.So I think for any couple with recurrent pregnancy loss,there are clear indications of the path ahead.And closes for optimism.It's not that you can cure every case,but the outlook for recurrent pregnancy loss is much better,much better than anticipated for the couple.

我很高兴和你们分享。反复流产这个话题一直是ESHRE的主要课题。反复流产对于一对夫妇而言是非常痛苦的。现在有很多单位、诊所专注于治疗反复流产并在反复流产的管理和治疗方面给出了非常棒的循证分析。所以我认为,对于反复流产夫妇而言,未来的道路是有迹可寻的,前景比较乐观。这并不是说每种案例都能治愈,而是反复流产的前景会变好,会比预期的更好。

3、Have you met the cases of spontaneous abortion after got pregnant with the help of ART?Or have you studied the ART-related spontaneous abortion?

临床中经ART技术获得妊娠后发生的自然流产的患者也有存在,您是否遇到过这类患者?或开展过ART技术与反复流产的相关研究

Pro.Farquharson  2018ESHRE年会大会主席:Oh,my goodness,yes,a in my career,in liverpool UK women's hospital,you see about 300-400 new cases of recurrent pregnancy loss all over the UK every year.So it was a matter of making sure that we got to know the patient and her partner,and we would instigate investigation scheme,which is comprehensive.And following that,we would see them back to discuss the results.And following that,we will ask them to consider achieving a pregnancy.As soon as the new repregnant with a positive pregnancy test,they will report to the clinic and we will see them every two weeks until they were at least twelve weeks.The good news is that at least 70% of couples with recurrent pregnancy loss will be successful in the subsequence pregnancy after they've had a full scheme and appropriate management.

That ART pregnancies are just as prone pregnancy loss as Spontaneous conception.And I think the biggest cause is spontaneous chromosome abnormalities.And of course,this release,obviously,within the ART two regarding implementation failure because we think of the government plantation that is to school of thought.One school of thought thinks it's all to do with the uterus.And it's about endometriosis activity that might be different or abnormal.But as the other school of thought thing is all to do with the embryo that because of persisting or spontaneous films about this,the fertilized egg cannot implant a prolific.

So the two schools of thought are right.And they're not right,because it's the interaction between the embryo and the individual interface that we don't understand completely.But we want to know more.The only problem for us,of course,is that spontaneous chromosome abnormalities in the fertilized egg cannot be corrected.And the university little vast majority of the.So there's not enough what we can do about that.Some centers of the world would like to manipulate the embryo by selecting only those embers with a normal chromosome to replace as a mere transfer in ART.But of course,the results so far,not sure that it's any better than doing nothing at all.Because,as I say,seventy percent of couples with recurrent pregnancy loss will achieve success.whether they have this intervention or not. So obviously mother nature is looking after us and securing a baby for the majority of couples in the future with recurrent pregnancy loss.

是的,在我的职业生涯中,在英国利物浦妇女医院每年你可以看到大约300 - 400反复流产的新增病例。这要求我们做到了解患者及其伴侣并且能为他们制定全面的计划。在那儿之后,我们需要再次见他们讨论检查结果。之后,我们将请他们考虑怀孕。一旦怀孕,他们需要定期向诊所汇报情况直到怀孕12周后。值得高兴的事,至少有70%的反复流产的夫妇按照上述步骤做完后,成功怀孕。

通过辅助生殖技术受孕一样容易发生自发性流产。我认为最大的原因是自发染色体异常。当然,这显然存在于辅助生殖技术常见的两个失败原因之中,因为我们通常将其归咎于不同的想法。其中一派认为失败是和子宫有关,可能是子宫内膜异常。而另一学派认为失败就是胚胎导致的,因为当我们持续拍摄可以看到,受精卵通常无法多次植入。

所以这两个学派的思想是正确的。而他们又不正确,因为这是胚胎和个体之间的交互作用,对此我们还不能完全理解。但是我们想知道更多。当然,唯一的问题是自发的异常染色体在受精卵时不能纠正,情况大多是这样。所以我们能做的还不足够。世界上的一些生殖中心可能会想通过选择拥有正常染色体的胚胎来操纵改变胚胎染色体异常的情况。当然,到目前为止,这种做法的结果还不确定,但这也比什么都不做强。因为,就像我说的70%患反复流产的夫妇会取得成功,无论他们是否使用这种干预。显然大自然母亲是照顾我们、保护大多数反复流产患者的婴儿。

4、Is there any move-on or update in the study of recurrent abortion? Will you share the progress with us?

您们近期在反复流产方面有没有新的研究?您们的研究进展或结论能否分享一下?

Pro.Farquharson  2018ESHRE年会大会主席:There is.There are various studies.In fact,the ESHRE meeting this week in barcelona, we have some groundbreaking randomized control trials that are trying out this compound that might modulate the immunology of the pregnancy,now immunimodulation and recurrent pregnancy loss has been linked together for many years.There are,for instance,two or three lectures in ESHRE this week,they will try and tell us that maybe it can be improved.But I think at the end of the day,we might be a little further forward,but that's not going to be an enormous breakthrough until we understand the whole fertilization process between experiment and egg much better.It is a lot of the causes are miserable or so we need to be aware and understand more.So the basic science of our understanding that will be presented this week will also increase our knowledge and understanding what might go wrong as well as what goes right.

有的。这方面的研究有很多。事实上,本届巴塞罗那的会议中,我们有一些开创性的随机对照试验,尝试该化合物会在孕期进行免疫学调节。免疫调节和反复流产的联系由来已久。例如,这周有两到三个ESHRE的讲座就是讲这方面,他们将试图告诉我们,情况也许可以改善。但我认为可能在结束一天的会议后,我们也仅有一点点进步。这不会是一个巨大的突破,直到我们可以理解整个受精过程和受精卵。我们需要注意和了解更多原因。所以本周我们理解的基础科学将让我们对正确与错误有更深刻的理解。

5、In the past decade,China has made progress in the reproduction field. And we know,there are many Chinese physicians attending the congress.Do you have something to share with the Chinese Physicians?

近年来,中国的生殖医学技术也在不断进步,也有很多突出贡献的专家、学者,本次大会也来了很多的中国医生, 最后您可以和中国生殖领域医生们 分享一些什么吗?

Pro.Farquharson  2018ESHRE年会大会主席:Definitely!First of all,we welcome our Chinese delegates.We love the fact that you come all the way to Europe to attend the meeting.But we see with ESHRE and all the e-source is collaboration.We see that collaboration is the gateway to the future.And to welcome delegates,doctors,scientists in china.This is very good because it allows us to contribute in both directions.And ESHRE is a team to set up more educational collaboration projects with China.And already today,we had interviews with various members of the Chinese medical community and Chinese ART community to find out how we can improve our educational links between Europe and China.So we're optimistic there for the future too.

当然!首先,我们非常欢迎中国代表。你们不远千里来到欧洲参加会议让我们非常感动。我们可以看出ESHRE及其所有的电子资源的本质都是协作。合作是通往未来的途径。我们欢迎中国的代表们、医生和科学家。这点非常好,因为它使我们能够进行双向贡献。ESHRE这个团队和中国有着许多的教育合作项目。今天我们刚刚和中国生殖学会数位专家探讨商谈如何寻求中欧合作的契机来改善我们的教育纽带。对此,我们对未来持乐观态度。

俄罗斯ICRM国际辅助生殖医学中心于1992年在圣彼得堡成立,是俄罗斯第一家也是最大的综合型生殖中心。发展至今,ICRM辅助生殖中心已经开设妇科、生殖科、男科、外科等科室,共有120多位医学博士组成的专家团队,具有多年临床经验,在促排方案、PGD/PGS染色体筛查诊断等方面已经取得阶段性成果。另外,医院具备国际先进的胚胎培育及存储设备,拥有全球空气质量洁净度最高的胚胎试验室和检测室,24小时自动程序管理,完美模拟真人子宫环境,保证试管婴儿生育的完美与健康。目前,ICRM已经完成近30000例健康宝宝的生育,2015年被列为俄联邦医保指定医院,普京总统多次访问,在技术、价格和法律保护方面具备综合优势。